| The use of extremely low-frequency (BEMER-typical) pulsed weak electromagnetic fields in the field of orthopedics (2004 |

Schütze, N. und Walther, M.: Lehrstuhl für Orthopädie, Universität Würzburg

Kafka, W.A.: Emphyspace, Int. Research Association, Kottgeisering

 

Abstract: The focus of this study was an investigation of the influence of molecular-biological regulatory mechanisms of human osteoblasts, done based on differential gene expression analysis (in vitro), by special, extremely low-frequency BEMER 3000-typical pulsed, weak electromagnetic fields (approx. 48/42 cm — oval flat coil, pulse rate 30 Hz, mid-maximum flux density up to 100 microTesla).

 

Automated microtitre plate supported luminometric ATP tests show that the proliferation rate increased significantly up to five-fold after only three-day incubation (with a total of five applications done at intervals of about 12 hours, each for a duration of 8 minutes) versus controls. The osteoblast cell material recovered from this incubation was used for isolating RNA for the following differential stud of the up- and down-regulated protein production using GenChip analysis.

 

Interestingly, no differences in cancer-relevant oncogene production was observed.

 

Ongoing studies using the polymerase chain reaction (PCR) support the current findings. The studies thus contributed to a better understanding of the therapeutic successes previously obtained elsewhere using the Bemer3000 system used here, particularly in orthopedics (e.g. osteoporosis, fracture healing).

 

Different isolated observations and reports from the literature allow the proposition that the biological effect of electromagnetic field effects – particularly those of the extremely weak and low-frequency (ELF) pulsed, wideband BEMER 3000 system – based on the influence of molecular biological regulatory mechanisms.

 

These effects should be objectivized by the use of this BEMER-typical pulsed, extremely low-frequency pulsed and low-energy electromagnetic fields (BEMER 3000 – ELFs) in the (in vitro) genesis of osteoblasts by by proliferation and DNA-GenChip analyses. In detail, the study should also provide support as to the question of in which clinical areas studies Studies would be reasonable, particularly in vivo situations, on the therapeutic  application of these electromagnetic stimulation (e.g. osteoporosis therapy, fracture healing).